Out of the 3 targeted therapies (trastuzumab, pertuzumab, ado-trastuzumab emtansine), trastuzumab is the only drug that has biosimilar. Regarding the trastuzumab biosimilar, the first biosimilars being registered in Malaysia were Hertraz and Zuhera back in 2018. Herzuma was then registered in Malaysia in 2019. Due to the introduction of biosimilar, the originator brand Herceptin (which contains the active ingredient trastuzumab) has reduced their price by 52%. (21)
The following table shows the available trastuzumab brands available in Malaysia (as of 31st Dec 2020).
| No. | Product name | Active Ingredients | Holder name | Year of Registration in Malaysia |
|---|---|---|---|---|
| 1 | Herceptin (original) | trastuzumab | Roche (Malaysia) Sdn. Bhd. | 2015 |
| 2 | Herzuma (biosimilar) | trastuzumab | Celltrion Healthcare Malaysia Sdn. Bhd. | 2019 |
| 3 | Zuhera (biosimilar) | trastuzumab | Biocon Sdn. Bhd. | 2018 |
| 4 | Hertraz (biosimilar) | trastuzumab | Duopharma Sdn. Bhd. | 2018 |